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Infinite life
In the main screen press: CIRCLE, L2, X, SQUARE TRIANGLE, R2, L2

Escaping from guards
Go to a high roof when chased. Kill the guards that appear. After a few kills they will either run or give up.

Saving citizens
Use the following trick for easy guard fights while saving a citizen. When trying to "save a citizen", run in, assassinate one guard with your hidden blade, then lock onto the closest guard and hold R1. When the guard comes in to attack, press Square to parry and kill the guard in usually one smooth, clean move. Repeat this for all guards to avoid taking damage.

Kill anyone without a penalty
After you beat the Game, when you go back to the story mode you can kill anyone without losing life.

Defeating the Master
When fighting the Master he will take away your ability to use radar and make it difficult to see. This also allows him to hit you once and kill you. Lock on to him and use a throwing knife against him. This will take away his power to blind you and make him easier to kill.

Saving citizens
Use the following trick for easy guard fights while saving a citizen. When trying to "save a citizen", run in, assassinate one guard with your hidden blade, then lock onto the closest guard and hold R1. When the guard comes in to attack, press Square to parry and kill the guard in usually one smooth, clean move. Repeat this for all guards to avoid taking damage.

Jerusalem: Assassination
When you go to Jerusalem and do the assassination with the guards surrounding you, do not try to fight them off. Instead, turn around and run up the ladder to get to the second floor. A short intermission sequence will show your target running away and up another ladder. Hold R1 + X and run across the chandeliers. The ladder will be to the right. Run up the ladder and another short intermission sequence will show your target on top of another building. Chase him down and have your wrist blade enabled (press Up) Then, press L1 to lock onto your target while still chasing him down. When you get close enough, the word "Assassinate" will appear for Square in the upper right of the screen. Press it and you will complete your task. After another intermission sequence, evade the guards by jumping onto building roofs, hiding, etc. Make your way over to the bureau to complete the memory.

Undefeatable
If you have anyone attacking you from 1 person to 1 million people, all you have to do is keep R1 down and block and make sure your back isn't turned to anyone that is attacking you and then when anyone goes to strike you whilst holing R1 press attack when they are about to hit you.

Throwing knives
To get more throwing knives, walk towards a thug (big guys with leather hoods) and punch them, the gaurds will stay out of a fist fight and when you defeat him you will get 1 throwing knife, or you can go up to a thug and lock onto him, then pickpocket him, this also gives you 1 throwing knife.

All flags and templars
To know where all the flags and templars are, just visit this website: www.assassinscreed-maps.com/Maps.htm then select what area you are in, it will show the positions of them, and pictures of them.

Defeating William of Montferrat in Acre
After the guards (or most of them) leave William, drop down from the castle and slay William. Afterward, "de-target" or deselect, and run up into the castle buildings and battlement to get away. This is the fastest way of completing the mission.

Easy fights
Only attempt this technique if they are fluent in the Rank 2 skill "Counter" and they have enough synchronization bars (a.k.a., life bars). One and a half rows of bars will do. When in battle, equip your hidden blade. With this equipped, all of your counters will score an instant kill. You can even instantly kill tougher ranked guards (for example, the Teutonic guards in Acre when hunting Sebrand). Also, most of the time using the hidden blade in battle will scare the last one or two (even three if you are lucky) guards, causing them to run away. However because you do not have a weapon that is sufficient enough to block a full sized enemy blade, all incoming attacks will hurt you.

Easier interrogation
After you get the "target" to a safe area to "interrogate" them, punch them first then "grab" them for faster completions. It will take about two grabs to quickly finish them. However, into the last three quarters of the game you may have to grab them up to, but exceeding, four times.

Unlocking doors
When you go to bed after Memory Block 2, you will notice your closet door is open. Hit any button to get a piece of paper Desmond notes as a code. The code will unlock your bedroom door which will allow you to be able to go out as often as you like after you are put to bed, as well as to open the meeting room area. You can also pick up various items to unlock Lucy's password.

Maximize efforts for each city
After killing Al Muaiam and returning to the real world, listen to the conversation about how they going to kill you. Turn on your Eagle Vision and look at the floor. There are some mixed up letters on both sides of the Amnius. You should see on the side closest to the main door:

M O R Y M N O E S
E N C E O L C H T
H O N B T L O T C
T D E O S A T O A
P E D S N L S T F
L D D U O O E T E
E A I E I R I N T
H S H K T T K E R
T U A A A N S S A

To decode this, start reading at the bottom right hand corner to the top right hand corner, so you will start at "A" and stop at "S". It will spell a real word. Do this for all of the columns and it will read:

ARTEFACTS SENT TO THE SKIES TO CONTROL ALL NATIONS TO MAKE US OBEY A HIDDEN CRUSADE DO NOT HELP THEM

Next, do the same thing to the mixed letters on the other side of the Amnius:

A
D R H
O O D T M
W H B I T D O
E U S Y S I N S E
A R O O M R E A Y N R
I S E Y T N I D L M I D E
T W I H W Y I E A U D A Y H T

It will spell out: THEY DRAINED MY SOUL AND MADE IT THEIRS I DRAINED MY BODY TO SHOW YOU WHERE I SAW IT.

Lucy's computer
One item you can pick up after being able to unlock your bedroom door is Lucy's password. You can then investigate her e-mails, which entail a short secondary story line. After you complete the last Memory Block, go back outside your room. Go to Lucy's computer. In "Deleted Items" is an e-mail which entails her talking to someone about a rescue, then the last reply comes back as:

WondEr Why It is everyone Laughs at you?
i'll Let you guess. let's just say she's
proBably gEtTing it bigger and better from
someone else tHat isn't you. how can you
hope to compEte? REst asSured there are
sOme gOod ways. click the liNk to see!

Removing the capital letters out of the message decodes the message as

WE WILL BE THERE SOON